Replies to post #70982 on Innovation Pharmaceuticals Inc (IPIX)

[sox040713]

I see where your confusion comes from. The 2011 poster does not sound like Kevetrin has the ability to restore mutant p53 to the correct protein folding, which is what David Lane was talking about.

"Kevetrin showed potent efficacy in many mutant p53 tumor enografts e.g. MDA-MB-231(breast ca.), HT-29 (colon ca.), NCI-H1975 (lung ca.), HCT-15 (colon ca.) (data not shown). We found that stable monoubiquitinated mutant p53 was induced by Kevetrin. This form of p53 has been shown to accumulate in the cytoplasm and mitochondria and retain the ability to interact with BAK or BAX proteins in mitochondria to induce apoptosis."