"Kevetrin showed potent efficacy in many mutant p53 tumor enografts e.g. MDA-MB-231(breast ca.), HT-29 (colon ca.), NCI-H1975 (lung ca.), HCT-15 (colon ca.) (data not shown). We found that stable monoubiquitinated mutant p53 was induced by Kevetrin. This form of p53 has been shown to accumulate in the cytoplasm and mitochondria and retain the ability to interact with BAK or BAX proteins in mitochondria to induce apoptosis."
This sounds like restoration of function of mutant p53.
They claimed in 2012 AACR poster pretty much what the web site says, that Kevetrin helps degrade mutant p53.
Thus my original confusion, wondering which was more important, and which effect Kevetrin primarily has - to stabilize mutant p53 into a form that still functions to promote apoptosis, or to degrade mutant p53?
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