Idenix Pharmaceuticals (IDIX)

[DewDiligence]

IDIX ReadMeFirst

[Updated Tyzeka script and launch info
and sales of competing HBV drugs.]


What is IDIX’s business all about?
http://www.idenix.com/about Capsule version
http://tinyurl.com/2uvynn Detailed version
#msg-23279256 Addressable markets for antiviral drugs
#msg-23278577 Drug pipeline


Valuation and finances
#msg-22707854 Valuation is cheap!
#msg-23242360 Restructuring of Tyzeka relationship with NVS
#msg-23249593 Conjecture on the new royalty rate
#msg-21777418 2Q07 financial results


Upcoming events
#msg-22980391 2007-2008 news flow


Officers, directors, and major shareholders
http://www.idenix.com/about/leadership Capsule résumés of executive officers (click on each name)
http://tinyurl.com/2fp2gz Capsule résumés of directors (page 5-6)
http://tinyurl.com/23shp3 Major shareholders
#msg-22707884 Protection from hostile takeover
#msg-11075184 CEO bought shares at $9.13


Tyzeka/Sebivo commercial program in HBV
#msg-23242360 Restructuring of Tyzeka relationship with NVS
#msg-23007328 Global HBV sales to reach $1.5B in 2010
#msg-23007224 US market is expanding rapidly
#msg-22707869 European market is large and poorly penetrated
#msg-23785846 Status of European launch
#msg-23434932 Treating asymptomatic e- patients will boost market
#msg-23007373 Prevalence of HBV by country
#msg-11099728 Asian immigrants are largely untreated
#msg-22771678 Tyzeka sales guidance for 2007
#msg-21358606 Why a slow sales ramp for new HBV drugs?
#msg-21388028 Bearish opinion by ‘gofishmarko’
#msg-23905127 Tyzeka US weekly scripts
#msg-23905293 Current Tyzeka scripts vs historical Baraclude scripts


Tyzeka clinical data
#msg-14377860 Two-year data from GLOBE trial
#msg-22771520 Tyzeka studies in progress
#msg-12271882 Tyzeka resistance data
#msg-14404551 Tyzeka’s efficacy comparable to Baraclude’s (1)
#msg-18389527 Tyzeka’s efficacy comparable to Baraclude’s (2)
http://www.fda.gov/cder/foi/label/2006/022011lbl.pdf FDA product label


Competitive landscape in HBV: general
#msg-23007224 Tyzeka competition
#msg-21652956 Prices of HBV drugs


Competitive landscape in HBV: Baraclude
#msg-22555240 Baraclude studies in progress
#msg-21652925 Baraclude’s black-box warning for HIV/HBV co-infection
#msg-21678537 Size of HIV/HBV co-infection market
#msg-21678801 Tyzeka’s edge in pre-menopausal women
#msg-23241377 Three-year Baraclude resistance data
#msg-23991491 Current Baraclude sales
#msg-24004519 Baraclude sales ramp 2005-present


Competitive landscape in HBV: Hepsera
#msg-23007224 Hepsera’s efficacy is inferior to Tyzeka’s
#msg-21460468 Gilead to cease promotion when Viread approved
#msg-23810770 Current Hepsera sales


Competitive landscape in HBV: Viread/Truvada
#msg-20743204 Phase-3 Viread data
#msg-22555241 Viread/Truvada studies in progress
#msg-20250616 Viread is structurally similar to Hepsera


Competitive landscape in HBV: Clevudine
#msg-23309283 Global phase-3 program
#msg-23359068 Musings on sustained virologic response (SVR)
#msg-14328142 Clinical results from Korea
#msg-20250616 Clevudine and Tyzeka are structurally similar (diagram)
#msg-20218516 Clevudine, Tyzeka are structurally similar (commentary)


Development program in HIV
#msg-17527610 IDX-899 selected as lead HIV candidate
#msg-22945614 IDX-899 development timeline
#msg-23279256 Addressable market for HIV drugs
#msg-22596568 Sustiva (the top NNRTI) sells almost $1B/yr
#msg-20997326 Phase-3 data for TMC125
#msg-23282517 Competing early-stage NNRTI’s
#msg-22980439 Pfizer’s UK-453,061
#msg-21895680 Importance of once-daily dosing


Development program in HCV
http://www.idenix.com/hepc/drug Description of HCV program
#msg-23279256 Addressable market
#msg-21197309 NM283 development discontinued
#msg-23031685 What’s ahead for HCV combination treatment?


Educational Links
http://www.cdc.gov/ncidod/diseases/hepatitis/b/fact.htm
http://www.who.int/mediacentre/factsheets/fs204/en
http://www.idenix.com/about/media/Glossary_of_terms.pdf
http://www.idenix.com/hepb/about
http://www.idenix.com/hiv/about
http://www.idenix.com/hepc/about
http://www.hivandhepatitis.com
http://www.hepfi.org