Amarin Corp Plc (AMRN)

[marzan]

Big thanks to TastyTheElf for taking the time to dig into the trial protocol and share this—really appreciate the effort. 🙏

Just to add a bit of clarity for everyone:

The Hazard Ratio (HR) numbers being discussed are based on real data from earlier studies. The ~0.694 (headline) and the ~0.35 (adjusted) come from Phase II results and analyses referenced in the protocol. The lower adjusted HR reflects corrections for differences in patient populations, which can make the treatment effect appear stronger.

The p-value mentioned (like 0.00000000000001) is not an actual reported number. It’s a hypothetical example, meant to show what the statistics might look like if the trial delivers a very strong result—such as an HR around 0.35.

In simple terms:
• HR shows how strong the treatment effect is
• p-value shows how confident we are that the result isn’t due to chance

So when you see a very low HR paired with an extremely tiny p-value, it’s just illustrating that a strong effect would likely come with very high statistical confidence.

Really interesting angle to look at—thanks again, TTE.