Monday, August 18, 2025 8:20:05 PM
Binary events will always take precedence to any chart pattern. Though a little different appearance, the Batman sign can be traded like a double top. I agree that $4 would only occur if MAA is withdrawn and schizo TLD is a complete bust. I don't think WS is attributing much of the market cap to Schizo. MAA approval (vs just next step in the process) would be huge but probably not in 2025 (imo unlikely at any time unless another P3)
The MOA of 3-71 overlaps with BMS/Karuna drug Cobenfy so excellent results will be nicely rewarded. I think mixed results (that would be nuanced in the PR to appear positive) will not get minimal reward. I think odds of a good P2 readout is reasonable - about 10% excellent results (in line with 8+ points reduction in the Positive and Negative Syndrome Scale (PANSS) total score compared with the placebo that was seen with Cobenfy), 15% good results (6-8 points and p< 0.05), 20% nuanced (< 6 points but p<0.05 or > 6 points but p>0.05), 55% < 6 points and p>0.05. A nuanced result could be spun in a PR as patients in the P3 KarXT studies were not on concurrent therapy vs 3-71 allowing 3-71 as add-on (this is possibly a design flaw in the A371 P2 that could come back to haunt Missling). Anything worse will be hard to spin when Cobenfy is already out
The MOA of 3-71 overlaps with BMS/Karuna drug Cobenfy so excellent results will be nicely rewarded. I think mixed results (that would be nuanced in the PR to appear positive) will not get minimal reward. I think odds of a good P2 readout is reasonable - about 10% excellent results (in line with 8+ points reduction in the Positive and Negative Syndrome Scale (PANSS) total score compared with the placebo that was seen with Cobenfy), 15% good results (6-8 points and p< 0.05), 20% nuanced (< 6 points but p<0.05 or > 6 points but p>0.05), 55% < 6 points and p>0.05. A nuanced result could be spun in a PR as patients in the P3 KarXT studies were not on concurrent therapy vs 3-71 allowing 3-71 as add-on (this is possibly a design flaw in the A371 P2 that could come back to haunt Missling). Anything worse will be hard to spin when Cobenfy is already out
Recent AVXL News
- Anavex Life Sciences to Present at the 25th Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 04/07/2026 11:30:00 AM
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- Form 8-K - Current report • Edgar (US Regulatory) • 03/25/2026 08:06:00 PM
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- Anavex Life Sciences Presents New Data from its AD-004 Phase IIb/III Trial at AD/PD 2026 Conference Demonstrating Consistent Correlation Between the Treatment Effect of Oral Blarcamesine and Preservation of Brain Volume in Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/23/2026 11:30:00 AM
- New Scientific Findings Highlight Hypothesis of Autophagy Failure as a Precursor of Amyloid Beta and Tau Pathology in Alzheimer’s Disease • GlobeNewswire Inc. • 03/20/2026 11:30:00 AM
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- Anavex Life Sciences to Present at the 46th TD Cowen Annual Health Care Conference • GlobeNewswire Inc. • 02/25/2026 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/25/2026 11:07:01 AM
- Anavex Life Sciences Appoints Seasoned Healthcare Leader to Board of Directors • GlobeNewswire Inc. • 02/23/2026 12:30:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/09/2026 09:40:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/09/2026 12:31:17 PM
- Anavex Life Sciences Reports Fiscal 2026 First Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 02/09/2026 12:30:00 PM
- Anavex Life Sciences to Announce Fiscal 2026 First Quarter Financial Results on Monday, February 9, 2026 • GlobeNewswire Inc. • 02/03/2026 12:30:00 PM
- Anavex Joins ACCESS-AD, a Major Initiative Funded by the European Commission, Through the Clinical Evaluation of Blarcamesine as Part of a Precision Medicine Approach in Alzheimer’s Disease • GlobeNewswire Inc. • 01/13/2026 12:30:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/09/2026 10:26:26 PM
- Edelson Lechtzin LLP Announces an Investigation of Anavex Life Sciences Corp. (NASDAQ: AVXL) and Encourages Investors with Substantial Losses Contact the Firm • PR Newswire (US) • 01/09/2026 01:13:00 AM
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- Anavex Life Sciences Receives FDA Feedback on Alzheimer’s Disease Program • GlobeNewswire Inc. • 01/06/2026 12:30:00 PM
- Anavex Life Sciences Submitted Request for EMA to Re-Examine Its Opinion • GlobeNewswire Inc. • 12/18/2025 12:30:00 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 12/12/2025 09:05:00 PM
- Anavex Life Sciences to Present Oral Blarcamesine Data at the 18th Clinical Trials on Alzheimer’s Disease (CTAD) Conference • GlobeNewswire Inc. • 11/26/2025 12:30:00 PM
