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Re: Pjay65 post# 484450

Friday, 03/07/2025 5:47:02 PM

Friday, March 07, 2025 5:47:02 PM

Post# of 515574
Jesse doesn't get into this directly, but I infer that lysosomes need a level of acidity to break down proteins to carry out autophagy, and that calcium ion transfers within the cell affects that activity, since calcium compounds have the ability to neutralize acids. Consequently, calcium channel failures* within a cell can impair autophagy, and impaired autophagy in turn results in accumulations of intracellular wastes that lead to neural dysfunction. Someone can correct me if I am misunderstanding this.

The S1R is known to restore this function.
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