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Re: Steady_T post# 444376

Wednesday, 12/27/2023 6:05:27 PM

Wednesday, December 27, 2023 6:05:27 PM

Post# of 468188
Here are links to a couple SAPs that are relevant to A273

Lecanemab/AD: https://www.nejm.org/doi/suppl/10.1056/NEJMoa2212948/suppl_file/nejmoa2212948_protocol.pdf The SAP starts at p. 397 (the link is to a merged file)

Trofinetide/Rett https://static-content.springer.com/esm/art%3A10.1038%2Fs41591-023-02398-1/MediaObjects/41591_2023_2398_MOESM3_ESM.pdf

As can be seen many many analyses are included in the SAP but the primary (or coprimary) endpoint(s) and exactly how it is (they are) to be calculated is key.
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