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Steady_T

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Re: Joseph_K post# 444362

Wednesday, 12/27/2023 2:41:48 PM

Wednesday, December 27, 2023 2:41:48 PM

Post# of 463208
There are ways to control for multiplicity. I think that in the case were are discussing that is why the p requirement was tightened up from p<0.05 to p<0.025 for both the primary and secondary endpoint.

Having never seen a SAP I'll take her word for it.

Multiplicity is mostly aimed at ad hoc analysis. If the alternate analysis is specified in the SAP it is not an ad hoc analysis. However, as I pointed out above, the p requirement is tightened up in the alternative analysis.

"Wise men talk because they have something to say, fools because they have to say something."
PLATO

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