NorthWest Biotherapeutics Inc (NWBO)

[HyGro]

Since you missed the ECA guidelines here is the key guideline that NWBO mised:
"Any matching on selection criteria or adjustments made to account for population differences should be specified prior to selection of the control and performance of the study."

NWBO clearly DID NOT make any "selection if the control" prior to the start of the trial. In fact it was done when the trial was virtually completed, 16 YEARS after the start of the trial.

FDA Guidance: "It is well documented that externally controlled trials tend to overestimate efficacy of test therapies."