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Re: Investor2014 post# 379697

Monday, 10/24/2022 2:38:47 PM

Monday, October 24, 2022 2:38:47 PM

Post# of 517600
Thanks, Investor, for your continued commentary on the blarcamesine alone having no significance in these trials. As you know I think otherwise since in the P2a trial those seven blarcamesine-only (Strong Responders) posted improvement during the first 31 weeks and for six remaining members through 109 weeks each still had higher scores in MMSE than they did at the start of the P2a. This was in contrast to most of the other 25 posting lower scores during 31 and 57 weeks (I didn't find data going out to 109 weeks for the DPZ users).

I acknowledge your point about Anavex not putting any significance to this, but we know how non-transparent Anavex and TGD want to be.

Actually, I look forward to that dive into the subset of participants w/o and w/ DPZ in a larger trial like this P2b/3. One thing that gives me some reassurance that w/o DPZ wins is that 2-73 Plus (blarcamesine + DPZ) wasn't used and has been thrown aside per pipeline and only notation of it in the history books is that it gained a patent. In fact, why didn't Anavex use Plus instead of 2-73 and DPZ separately which would allow participants to take one pill rather than two?

Time will tell, shortly.

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