Anavex Life Sciences Corp (AVXL)

[Investor2014]

No I don't think so and yes I have no doubt that co-administered psychoactive medications, such as Donepezil, will be part of the KEM subgroup analysis just as it was in the P2a study.

By what theory, other than a biased one, would Donepezil not better the earlier administrated in the AD disease progress?

The earlier the better seems to apply to A2-73. Early or prodromal treatment is a main thesis by most AD research.

Unsurprisingly this idea has been tested also for Donepezil: Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial

Conclusion: These data suggest significant treatment benefits of donepezil in early-stage Alzheimer disease, supporting the initiation of therapy early in the disease course to improve daily cognitive functioning.