NorthWest Biotherapeutics Inc (NWBO)

[biosectinvestor]

There was no post hoc data dredge and they knew that they had this crossover arm and could look for the same benefit as they had with the treated patients using the external control arm. All of it was approved before unblinding. You use the data dredge term that AF uses with other trials all the time because it sounds serious. It didn’t happen here. Sorry. What was measured was what they decided to measure given the circumstances and the previous determination to let the trial run and get the survival data. If PFS was the aim, the purpose of that endpoint is explained in my other posts and they’d have ended things earlier. The purpose of PFS is to get an early result.

OS is a concrete result, not a correlation with survival, but survival itself. Data dredging is for surrogate results, not a concrete result like beating hearts at the end of a trial where beating hearts typically no longer remain.