Another interpretation of AUC would be RSBQ was measured several times say week 1,3,5,7 and the total score was added up and compared between treated and placebo. (this method might especially be good if the 5 week or 3 week data looked much better than the 7 week final data)
There is nothing wrong with an endpoint like this unless it is post-hoc and better than the original endpoint. Missling MUST explain this at 830 or else results are open to interpretation.
I think this is the source of the SP reaction (12.76 as I write)
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