Anavex Life Sciences Corp (AVXL)

[falconer66a]

My error. But PRE-084 still produces amyloid-beta.

you think Pre-084 is an antagonist? I guess > 100 papers about the drug are wrong.

Thank you for the clarification, re the numerous papers showing that it’s not an ‘antagonist.’

My error of terminology, however, does not change the finding of the paper, which was that PRE-084 specifically caused increased production of amyloid beta. Whether it’s an ‘agonist’ or ‘antagonist’ is not nearly as important as that it actually produced the Alzheimer’s biomarker.

Of course, what’s needed is a comparative study matching the Anavex drugs (blarcamesine and Anavex 3-71) with PRE-084. Which sets of mice will have increased amyloid beta, and which will have decreased amounts?

Of course, the referenced study already definitely shows that PRE-084 increases amyloid beta. Have any of the multitude of murine studies shown this for either of the Anavex molecules? Nope.

A meta-analysis (comparative study) of existing papers of murine studies with PRE-084 and the Anavex drugs will clarify the issue (if there is one). In none of the papers on Anavex drugs in mice have I found a single finding of increased amyloid beta. Just the opposite in the referenced PRE-084 paper.

I’ll take no further interest or concerns with PRE-084. In regard to the Anavex drugs and the treatment of CNS diseases, it’s irrelevant.