Great points power! Alot of talk on one side or the other about “peekyboo” but another few scenarios that may in play are:
1) 2 very intensely studied peer reviewed papers are past due and are due any day.
2) Every Ph 2, in 3 different diseases will of had a peer review and went (and or most likely will “go”) into a pivotal Ph 3.
3) 2 more Rett partial readouts on top of this in the next 3-6 months
4) Initiation of a “Preventative dementia trial” in the next 6-12 months
4) Ph 3 Fragile X initiation in the next 6 months
5) Ph 3 for an Undisclosed rare disease. •’On a side note, this is the wildcard in play imo. Dr M mentioned recently that “ we have got to get this trial right, we have so many great pre clinicals to choose from, we need to pick the right/best one.” (Paraphrased)
6) “Highly enrolling/Enrolled OLE’s in every disease.
The list goes on and on and on….. what I see, if any, relating to the interim Ph3 Alzheimer’s trial peek is that Dr M would only consider looking early for a major benefit. One such benefit would be for it to further corroborate aaalllll the data to date. In other words, after the remaining pivotal Ph 2/3 start and Peer reviewed papers are out, it somehow, its results on say the first 225 in AU would seal the deal for one giant, extremely combed, data set package (some up to 6 yrs for safety) ends up being submitted for the rolling start to one giant Ph 4. Look at the evidence above, thats what it is! The snowball is rolling down hill, getting larger as it rolls picking up speed and many, many more will come all for one drug! Get ready folks! There is no coincidence that the trials were started in a carefully staggered stage, with “minor delays”/ accelerations, to end up with most if not all of each trials data coming together at one point in time.
“The front end of our work (proving cellular homeostasis) is/will be very time consuming and difficult but in the back end (after our master protocol/umbrella/Ph 4 “ preventative trial starts) we will see great benefit/ease from it (adding rolling pre clinicals to “it” as Ph 3’s ).” (Again paraphrased and I added all words in parenthesis)
In closing, this emergence or moreover the explosion of data to date as a slow volcanic eruption shooting high into the air, large safe clouds of symptomatic relief high into the air slowly encompassing all regions of the world!
We got this!
Tred
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