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Re: S_mack post# 366370

Thursday, 04/01/2021 12:02:59 PM

Thursday, April 01, 2021 12:02:59 PM

Post# of 698892
Endpoints are changed in numerous trials all the time.
If you do it before unblind and get regulator approval to do so, it's not a major issue. A regulator should not approve an endpoint change, if they think it is not warranted or justifiable given all the prevailing circumstances.
So nothing has changed. We know that at least two of the three major regulators have green-lighted the new endpoints.
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