Amarin Corp Plc (AMRN)

[sts66]

I have to back off on at least one of my claims - it appears a 1 g cap of V does indeed weigh a lot more than 1 g, it's actually 1.4 g or 1.5 g, so my "nobody could swallow a cap of V 50% bigger", while still true IMO, doesn't apply here. What we need to focus on is not the 25% sorbitan, but the 60%-80% of EPA - is that per 1 g capsule, or per actual probable weight of 1.4-1.50 g capsule***? The MSDS is very unclear about this - I assume "Mixture" applies to other ingredients, but those aren't even listed:

1 gram capsules are supplied as a clear, oblong capsule filled with colorless to pale yellow oily liquid and printed with “54 648” in black ink on one side.

Substance/mixture :
Mixture

Ingredient name 1,4-anhydro-D-glucitol % ≥10 - ≤25
Glycerol % ≥10 - ≤25

Active pharmaceutical ingredient
Icosapent Ethyl 60-80%

Any concentration shown as a range is to protect confidentiality or is due to batch variation.

There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.

*** For instance, if total capsule weight it 1.5 g, 60% EPA is 0.9 g, 80% is 1.2 g, for a 1.4 g cap, that's 0.84 g and 1.12 g EPA, which except for the bold number, all fall into the range where that article on the "Myth of 80%-125%" says is needed to meet bioequivalence standards. What's really bothering me is the huge range of 10%-25% for sorbitan - if that's the capsule shell, it shouldn't have anything close to that big a range of variability - it's not like your putting layers of paint on a blob of API to create a capsule.