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Re: Doc328 post# 257612

Monday, 07/06/2020 11:39:12 PM

Monday, July 06, 2020 11:39:12 PM

Post# of 517712

I'm not expecting benefit of A273 for tremor in PD.

Preclinical study indicated otherwise.

Dosing of ANAVEX 2-73 daily for five weeks in a 6-hydroxydopamine lesions mouse model of Parkinson’s disease was followed by a battery of standardized tests that are linked to parkinsonian motor symptoms. The data indicates that ANAVEX 2-73 is well tolerated, induces significant motor recovery (p<0.05), induces neurohistological restoration (p<0.05) and reduces microglial activation (p<0.05), a potential biomarker of Parkinson’s disease. Behavioral patterns were completely normal, meaning no signs of either dystonia or stereotypic behaviors were detected in animals receiving the treatment.

www.anavex.com/anavex-life-sciences-drug-shows-efficacy-to-support-potential-disease-modification-in-parkinsons-disease/
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