Anavex Life Sciences Corp (AVXL)

[anders2211]

DOC I have a question you said:

I'm not expecting benefit of A273 for tremor in PD

Is this specifically only for PDD patients? because for the RETT patients in the trial Anavex dit report an improvement in motor skills

In addition to the significant improvements of the two global efficacy endpoints, the Rett Syndrome Behaviour Questionnaire (RSBQ) Total score and the Clinical Global Impression – Improvement (CGI-I), the RSBQ Hand Behaviours and the RSBQ Breathing Abnormalities improved during the trial.

Also because in a previous post you said:

A273 is an M1-M4 agonist and S1R agonist. In PD, there is a selective loss of dopaminergic neurons, especially in the substatia nigra (pars compacta). These neurons project to the basal ganglia. DA and M4 receptors co-localize in many neurons in the BG. DA is inhibitory and ACh )acting through M4) is excitatory. Tremor is caused by the imbalance of these input signals. Hence, M4 activation is unlikely to help tremor and actually may worsen the imbalance of the inhibitory / excitatory inputs to the BG

thanks for answering