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georgejjl

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georgejjl

Re: bas2020 post# 256545

Saturday, 06/27/2020 2:26:28 PM

Saturday, June 27, 2020 2:26:28 PM

Post# of 515625
Entire DNA and RNA sequencing is done during initial screening as an input as part of the recruitment process (see slide 23)

http://www.anavex.com/wp-content/uploads/2020/06/Anavex-Presentation-June-2020.pdf

Genetic variants SIGMAR1 (rs1800866), COMT (rs113895332/rs61143203) with
influence on treatment effect

How the gene variants influence on treatment effect are readily apparent at the conclusion of the trial. This is similar to how the dose levels influence on treatment effect.

They do introduce confounding variables into the analysis of the effects, but these are easily handled by the statistical analysis software.

Good luck and GOD bless,


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