Tuesday, October 17, 2017 9:19:42 AM
In my opinion, historical controls will be used more and more since there is just too much data and information to be utilized in adaptive trial designs. It is only logical that this information rich and time tested and reviewed huge data set is utilized, though, it is of course an area which will require much depth and understanding to apply. It is a perfect complement to AA, with confirmation to come post. It is not an easy endeavor and not without risks, or, it would have been used much more in the past. But, the time has come to build on well captured data and science to make for more efficient drug development.
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