Anavex Life Sciences Corp (AVXL)

[CkFacts]

Insomnia , Dementia and A 2-73

Thanks for posting this new article Bourbon !

I have owned AVXL shares since 2007 and have been following closely this research since ca 2012 which clearly shows an "association " between insomnia and dementia . The two elderly family members with alzheimers for whom I am PoA and part -time caregiver both began ( 2012/2013 ) with sleep disturbances , insomnia , night wandering , etc which progressed by 2014 to full alzheimers .

I don't believe that it is known yet "which is the chicken and which is the egg " , however the fact that our A2-73 appears to work on both Alheimers and insomnia only strengthens the likelihood of a strong connection , as does the recent research which has shown that most "brain cleansing " only occurs during deep REM sleep .

Earlier this week , Dr . Rudi Tanzi, a leading Alzheimer researcher ( Harvard , Mass. General , etc ) was on the Dr. Oz Tv show and reported on some recent ALZ research presented in July at the AAIC in London , and also some of his own lab studies .

He reported that the presence of bacteria and viruses in the brain was receiving greater attention , and the formation of plaque may actually be a related defense mechanism . He said :

" We used to think that it took years for plaque to form but it turns out in studies we have done that one bacterium or one virus can trigger a plaque overnight ! "

" We have always thought that this stuff was just junk but it protects the brain against infection Plaque acts like a jail which traps the infection . Instantly this stuff accumulates around the little pathogen and intraps in infection . This is a whole shift in our thinking ! " He further noted that the accumulation of plaque will lead to alzheimers .

However , in my humble opinion , I guess one could also argue that " alzheimers/ insomnia " can lead to plaque accumulation ?!

I believe that our A 2-73 , by promoting Cellular Homeostasis ( at various stages / areas of brain function) will allow " deep sleep " and proper " brain cleansing " . I pray that it may also have a curative effect on already diseased brains !!

GTAL