Very helpful post, CKfacts, and the info you posted about sleep/insomnia/dementia/2-73 appears to me to have some connection with reduction of oxidative stress.
Talon38 posted this article/interview with Dr George Perry back in early Aug 2017:
Excerpted: "Perry himself has published around 1,000 pieces on Alzheimer’s disease, making him the nation’s leading Alzheimer’s researcher. He is currently the editor-in-chief of the Journal of Alzheimer’s Disease."
"After 30 years and $24 billion invested in efforts to reduce plaques, Perry’s hypothesis is controversial. Investment, however, cannot truncate the scientific process."
"Just like other aspects of physical health that deteriorate with age, “you can do a lot to do reduce your chances of having the disease,” Perry explained. When patients present with Alzheimer’s, he said, many of the cells in their body – not just the brain – show signs of stress."
"He recommends reducing the oxidative stress within the body with the tried and true elements of “good, clean living:” lots of fruits and vegetables, exercise, reduced stress, and a reason to live decrease the likelihood of Alzheimer’s by 50%, Perry said."
My take: it's an interesting correlation (from the nation's leading Alzheimer's researcher) to Anavex's approach of reducing oxidative stress:
6:34 in the June 2017 Jefferies presentation, per Dr Missling: "It's also been shown with our drug that very nicely dose dependently it reduces oxidative stress"
Slide 13 from June 2017: "Confirmed effects of Sigma 1 receptor activation.... Reduces Oxidative stress" and "Anavex 2-73 is an orally-available, small molecule activator of the Sigma 1 receptor restoring cellular homeostasis by targeting protein misfolding, oxidative stress, mitochondrial dysfunction, inflammation and cellular stress, factors in both neurodegenerative and neurodevelopmental diseases."
LASTLY, this NIH study had the below results and conclusion (EMPHASIS on the conclusion "REM sleep deprivation is a potent oxidative stressor"):
"Results This study showed that 96 hours of REM sleep deprivation results in increased lipid peroxidation and reduction in total reduced glutathione level in the discrete regions of brain studied. However following restorative sleep for 24 hours all the changes reverts back to base line value. This study shows that oxidative stress produced by 96 hours of REM sleep deprivation is reversible.
Conclusion From this study it is clear that, REM sleep deprivation is a potent oxidative stressor. This could probably play a role in the behavioral and performance alteration seen in both experimental animals as well as humans following REM sleep deprivation. Further investigations in this line are needed to highlight the importance of REM sleep."
I posted about 273 on the HMS article site, but so far the censor isn't letting it through. Maybe on holiday?
Also sent it to the woman researching FFI at Harvard...so far no acknowledgement. Either she is another "not invented here" type or maybe is checking it out first.
So much in science, especially medicine, has this problem:
Truth takes years to overcome "accepted opinion".
But I would have thought a future sentence of FFI would have made her think differently.
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