NorthWest Biotherapeutics Inc (NWBO)

[Rkmatters]

It brings up an interesting topic. My bet is that they find antibiotics treatments that are commonly used to treat leukemia patients affected the patient's microbiome and that caused an overreaction to JUNO therapies.

With immunotherapies a "healthy gut" is just as important as the therapy itself. One of the reasons that I postulate that a therapy like DCVax-L restores chemotherapy ability to work is that it the modulates the MHC to bring T helper cells back in balance.

Any patient or frankly, anyone who has ever been on any antibiotic needs to get on a probiotic to restore their natural immune response. Antibiotics may actually leave patients susceptible to cancer, specifically relapse. They are learning more each day on how important a healthy gut may actually affect naturally immune system and immunotherapy. All immunotherapy cancer patients should be on Probiotics. Possibly all cancer patients should be on probiotics. I'm certain that UCLA is aware of how proper nutrition affects the immunotherapies.

The company isn't planning to use Cyclophosphamide just because. They are well aware how it affects the gut positively. :)

Some interesting reads to try see what I do about harnessing the gut:

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.778.7750&rep=rep1&type=pdf


https://www.google.com/amp/www.the-scientist.com/%3Farticles.amp/articleNo/45616/title/Microbes-Meet-Cancer/?client=safari

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339017/pdf/nihms662663.pdf