Avid Bioservices Inc (CDMO)

[aikifredicist]

If I recall correctly Peregrine planed the subverted Phase II trial with 1 mg and 3 mg arms. At that time they stated that according to their calculations the 1 mg dosage should suffice. After the Fargo disaster, they stuck with the 3 mg for Sunrise. The Fargo 3 mg arm appeared to perform well. As you say perhaps too much Bavi and not enough B2-Gp1 will result in ineffectual one armed Bavi floating around depleting the B2-GP1. I find it still interesting that mch1N11 dosing does not seem to have that problem in the mouse model. The Sloan-Kettering people did not test for B2GP1 levels. I doubt if any of the other mouse tests looked at it either.

--- Umm.. I'm getting a headache.