NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

iwasadiver,

To tell you the truth, I am a little giddy about what I think I have found and yes I do know the difference between fools gold and the real deal. I learned lots of cool stuff in 5th grade.

I hesitate to reveal too much because many have poured their lives into all of this and I certainly don't want to give competitors a chance to catch up but I am sure my comments with clues have caught the attention of several folks. The bottom line is that very specific types of differentiation matter with regard to DCs and other cells and there are certain clues from various sources about what NWBO might be doing to make their DCs special. For NWBO the differentiation that matters most is done ex-vivo and is therefore not naturally ocurring. This makes it a strongly patentable process. Anyone can mature precursors to DCs but they can't mature them with the exact same properties that NWBO can. Anyone can make a cola but only one company can make Coca Cola. Now add to this Triozzi et al's observation that intratumoral injection of DCs helped to temporarily change the tumor microenvironment and that intratumoral injection coupled with intradermal injection appear to be synergistic and you have the reason for my investment here.

There are a few key steps along the way to success and I believe I researched my way into stumbling onto 3 of them. Activation and the intratumoral setting sets Direct apart and additional research could eventually lead to at least semi standardized vaccination. With regard to DCVax-L and brain tumors, the immune system must work efficiently and at a much slower pace than what can be achieved using certain other immunotherapy methods so as to prevent dangerous swelling. Apart from this situation Direct or Direct/L could eventually be used to treat all other solid tumor cancers and most likely at almost any stage except perhaps very end stage cancer but spacing of the treatments appears to be critical for this to be achieved. Again, the type of DC is important and there is at least one subset they found in the Phase 1 Direct trial that NWBO is very excited about. Best wishes.