Replies to post #176072 on Biotech Values

[iwfal]

EXEL -

Do you think then they designed COMET-1 for non-proportional hazards? That would reconcile the info in David Miller's post.

? What needs reconciliation? Everything reconciles to the sig figs given.

E.g. the trial was probably designed with assumed HR=0.75, 90% power (math vs patient planned for final trigger is almost perfect match). As per David's post placebo arm got 7 months - which implies that treated arm would be about 9.3 months. But in a conf call or conversation I would actually expect them to round - i.e. call the 9.3 months "9 month"