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Re: hirogen post# 176072

Thursday, 03/27/2014 9:27:54 AM

Thursday, March 27, 2014 9:27:54 AM

Post# of 257556
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Do you think then they designed COMET-1 for non-proportional hazards? That would reconcile the info in David Miller's post.



? What needs reconciliation? Everything reconciles to the sig figs given.

E.g. the trial was probably designed with assumed HR=0.75, 90% power (math vs patient planned for final trigger is almost perfect match). As per David's post placebo arm got 7 months - which implies that treated arm would be about 9.3 months. But in a conf call or conversation I would actually expect them to round - i.e. call the 9.3 months "9 month"

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