I feel for you, trust me - you have plenty of company there - between my IRA and cash account AMRN is my second largest position by cost, ARNA #1 (also own that in my ROTH), the current paper profits of which nearly balance out the paper AMRN losses, net is ~ -10% down. A few weeks ago net was positive, but ARNA has been hit along with the entire bio sector, dropped from $7.53 on Jan 22 to $6.00 as of COB today.