jellybean
<Yes, i find the concept that a silent mutation could be responsible for a human disease important, and my pushing on you was to figure out if this was real or the ramblings of a chatboard know-it-all. I had no intention of wasting my time based on the first pieces of information that you referenced. Here's the data from a recent review (thanks Genisi for a solid reference). Some of the data is tentative and the correlation with changes in folding rates are negligible. >
I do find it amusing that someone who claims to be interested in a topic refuses to even do a minimal search to find out about it. I never claimed to be an expert on synonymous mutations and how they might affect proteins or even mRNA. In fact, I made this quite clear in my comments that I had minimal knowledge based on a journal club a few years ago.
So, did you do any of your own google searches or are you too lazy so are simply reading the review posted by Genisi?
Did you read the other references I gave you?
What is even more amusing is that you seem to be grasping at any piece of data to dismiss or minimize the phenomenon of synonymous mutations potentially having effects on proteins. It doesn't matter how weak or rare the phenomenon is, what matters is that it is real and in some cases has significant effects. Hell, if one used your logic you could argue that the hypothesis that non-synonymous mutations affect proteins and or mRNA is tentative and correlations with folding rates are negligible because many such changes have little or no effects.
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