Replies to post #142903 on Biotech Values

[DewDiligence]

From your reference:

Interestingly, the delta-RSCU values show both positive (in 21 cases) and negative values (in 25 cases). This suggests that synonymous mutations might either increase or decrease local translation rates.

[jellybean]

Yes, and thank you. Not only am I too lazy to search Google for academic papers, but I am too lazy to figure out how to upload references, and so just cut and pasted the table which dropped all the formatting. The phenomenon is intriguing, but I do wonder whether the correlation is over-interpreted given the complexity of human genomes; maybe there are additional mutations at other loci that also come into play to drive the disease. Afterall, the original work from E. coli showed that multiple, consecutive silent changes were needed in a coding region to cause a change in protein levels or protein activity.