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NP1986

05/23/12 12:44 AM

#142409 RE: iwfal #142408

Agreed - but it is an interesting and non-intuitive effect. Damaging the OS I can understand (via toxicity to patient), but accelerated tumor growth commonly occurring across the meta-class is just very counter intuitive to me.



Toxicity could also explain the effect on PFS, if it leads to early treatment discontinuation.

Treatment-related deaths would also be counted as an event for PFS, wouldn't they?