Support: 888-992-3836
Copyright © 2023 InvestorsHub Inc.
Replies to post #140510 on Biotech Values
jq1234
04/19/12 10:43 PM
#140511 RE: DewDiligence #140510
DewDiligence
04/22/12 3:20 PM
#140599 RE: DewDiligence #140510
06/26/12 6:27 PM
#144554 RE: DewDiligence #140510
During the 3-day treatment period, mean maximal HCV RNA reductions for the 4 dosing groups were: • 3.2 log10 IU/mL in the 40 mg dose group • 3.5 log10 IU/mL in the 80 mg dose group • 3.5 log10 IU/mL in the 160 mg dose group • 3.7 log10 IU/mL in the 240 mg dose group There was only one minimal-responder in the trial. A patient in the 240 mg dose group was found to be fully resistant at baseline with 100% of this patient’s pre-treatment HCV RNA containing 3 genetically linked NS5A resistance mutations. This patient was excluded from the efficacy analysis of the 240 mg cohort… …A protocol amendment has been completed to explore the pan-genotypic clinical efficacy of PPI-668 in HCV genotype-2a/3a patients. [I object to the word “pan-genotypic” here, but that’s a nitpick.] Recruitment is currently underway for this added cohort.