Replies to post #125650 on Biotech Values

[projectchris]

Bone met population by 4 tumor types other than prostate presented at ASCO


Melanoma 20/77 (26%) 2/2 available to show partial bone scan response


Breast 14/20 (70%) 2/3 availabe to show partial bone scan response 1 patient stable


NSCLC 17/60 (28%) 0 available


Ovarian 6/70 (9%) 0 available

[biomaven0]

A quick search turned up the following abstract indicating that bone mets are more common than one might think in late stage gyn cancers:

Gynecologic Oncology
Volume 39, Issue 2, November 1990, Pages 108-114
doi:10.1016/0090-8258(90)90414-G | How to Cite or Link Using DOI Cited By in Scopus (61)
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Regular article
Bone metastasis from gynecologic carcinomas: A clinicopathologic study

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Fadi W. Abdul-Karim M.D.,
...
Received 10 May 1990. Available online 11 April 2004.
Abstract
Between 1948 and 1984, autopsies were performed on 305 patients with primary carcinomas of the cervix, endometrium, ovaries, fallopian tubes, vulva, and vagina. Skeletal metastases were detected premortem and at autopsy in 49 cases (16.1%): cervix, 20 (40.8%); endometrium, 17 (34.7%); ovary, 7 (14.3%); vulva, 4 (8.2%); fallopian tube, 1 (2%). There were no cases of osseous metastasis from vaginal carcinoma. The incidence and sites of metastasis from these gynecologic carcinomas were correlated with their clinical and histopathologic classifications. This clinicopathologic study, based on autopsy data, demonstrates that osseous metastases are not uncommon, are significantly greater than clinically appreciated, and correlate with advanced anatomic stage and histopathologic type and grade.