Replies to post #125592 on Biotech Values

[projectchris]

I really don't see reduced osteoclastic activity in late-stage patients without known bone mets as concerning at all. It's cerainly plausible these patients have occult bone mets which haven't yet shown up on a scint scan. Be nice to know if their pre-treatment CTx levels were elevated.

journals.lww.com/corr/Abstract/2003/10001/Diagnosis_of_Occult_Bone_Metastases__Positron.16.aspx

Peter

I personally don't either. I also find the rise in hemoglobin with non metastatic bone disease as interesting for anemic patients. I wonder if metastatic crowding is occurring on micro/occult level in bone marrow much like you describe could be happening with regards to elevated CTx levels.

[iwfal]

EXEL

I really don't see reduced osteoclastic activity in late-stage patients without known bone mets as concerning at all. It's cerainly plausible these patients have occult bone mets which haven't yet shown up on a scint scan.

In non-PC patients (I.e where Bone mets much less common)? Of the almost exactly the same distributions and magnitude. I'd suggest that borders on the incredible. And if the same effect exists for anemia (which I missed) then that too begs questions IMO - although not as obviously incredible IMO.