I really don't see reduced osteoclastic activity in late-stage patients without known bone mets as concerning at all. It's cerainly plausible these patients have occult bone mets which haven't yet shown up on a scint scan. Be nice to know if their pre-treatment CTx levels were elevated.
Page 25 of the investor briefing describes hemoglobin changes across all tumor types. Exelixis did a poor job of highlighting this point on title of this page.----I could be mistaken but believe that is what I heard from the webcast accompanying slides.