Replies to post #120265 on Biotech Values

[biomaven0]

Do you think that there is a mutated gene for every cancer out there and its just a matter of finding the switch to turn it off like they have been able to do with ALK and BCR.ABL, and Hh?

No - examples like ALK and BCR/ABL are the exceptions rather than the rule. In most cancers there is a lot more going on than a single gene stuck in the "on" position.

But you might yet see more magic with the right combination therapy in these more complex cancers.

Peter

[DewDiligence]

(ARIA)—On PFE’s ASCO webcast yesterday, Mace Rotherberg (SVP, oncology) noted that many—perhaps even most—cases of resistance to Crizotinib stem from reasons other than a mutation in ALK.