Replies to post #115166 on Biotech Values

[iwfal]

Yes, it is possible that the drug is somehow blocking the osteoblastic pathway - that would mean that bone mets would not progress (or show up on these scans)

I do not believe that blocking the osteoblastic pathway necessarily causes stabalization (i.e. non-progression) of bone mets. It might. But far from obvious to me that it must.

[DewDiligence]

Bone mets: There are complex feedback loops driven by poorly understood growth factors, so that intervening with osteoclasts affects osteoblasts in somewhat unpredictable ways. AMGN’s Roger Perlmutter could carry on for several hours about this.