Replies to post #115008 on Biotech Values

[DewDiligence]

EXEL—Of 62 patients evaluable by bone scan, 53 (85%) achieved either complete or partial resolution of metastatic lesions on bone scan by independent radiologist review.

Was the CR-vs-PR breakdown disclosed?

[BTH]

This all sounds very good...

However, this is Exelixis the company of hype and under-delivery, so can someone make a breakdown of this?

[dumaflotchie]

Prostate-specific antigen (PSA) changes were observed to be independent of reduction or stability of tumor target lesions, resolution of bone lesions on bone scan, and changes in bone pain.

What do you make of the lack of PSA coorelation? This lack of coorelation has been demonstrated in other studies early on but the PSA has been used by so many to track recurrence of this disease. Maybe too early in followup to identify trend?

Practically everything else points to response from anemia improvement to reduction in alk phos to bone scan improvments.......but not PSA.

Is this an anomoly or commonly seen?