Prostate-specific antigen (PSA) changes were observed to be independent of reduction or stability of tumor target lesions, resolution of bone lesions on bone scan, and changes in bone pain.
What do you make of the lack of PSA coorelation? This lack of coorelation has been demonstrated in other studies early on but the PSA has been used by so many to track recurrence of this disease. Maybe too early in followup to identify trend?
Practically everything else points to response from anemia improvement to reduction in alk phos to bone scan improvments.......but not PSA.