I think we are dealing with two different definitions of naked.
Acuity Pharma’s AMD candidate uses “naked” siRNA in the sense that it hasn’t been chemically modified to make it a better drug. ALNY’s siRNA is heavily modified but is “naked” in the sense that it does not use a vector to enter cells, relying instead on the chemical modifications to the siRNA.
>>All drugs (including si) are dirty<<
The “dirtiness” will depend on the extent to which VEGF is needed for normal retinal functioning. That VEGF plays some beneficial role in normal retinal functioning is a matter of dispute in the industry, with EYET being the main proponent of this hypothesis.
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