if i recall NVS dropped the first FOB project because the commercial opportunity was not compelling any longer - orencia's somewhat disappointing sales fit that bill
These drugs are competitors for the non-TNF-a segment of the RA market, usually in the third-line setting (following methotrexate in the first line and one of the TNF-a drugs in the second line). Roche’s Actemra is a distant third to Orencia and Rituxan in this market segment.