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AlpineBV_Miller

08/27/10 6:03 PM

#102771 RE: DewDiligence #102745

From a practical standpoint, the two phrases mean essentially the same thing.



They actually don't in cases where newer therapies increase tolerability and have higher therapeutic indexes. Proving either is not necessarily a quicker path to approval. The difference between the two phrases is likely to grow over time (couple decades) as pharmacoeconomics works into the equation.