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rkrw

08/27/10 9:12 AM

#102697 RE: iwfal #102695

Those are just low grade lesions that can be removed, a small side effect considering they have metastatic melanoma.

I don't think avoiding the sun would have much impact in this case.
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DewDiligence

09/19/10 2:24 PM

#104567 RE: iwfal #102695

Interesting question is whether the incidence of squamous cell carcinoma [while taking PLX4032] can be avoided just by rigorously avoiding the sun - or is it previous sun damage that is turned into squamous cell carcinoma?

Another question is whether the typical melanoma patient will be willing to stay out of the sun while taking PLX4032. From the NYT article in #msg-54567652:

In April, Mr. McLaughlin donned a bandanna, a sun hat, a long-sleeved shirt and pants and went to a job building fences on a nearby ranch. The [PLX4032] pills, he had vowed, would not prevent him from working outside.