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iwfal

08/27/10 9:22 AM

#102700 RE: rkrw #102697

a small side effect considering they have metastatic melanoma.



Ok, agree that it isn't a huge safety issue compared to the existing melanoma. But I have never heard of any treatment anywhere that creates even close to 40% incidence of a significant cancer within a few months. That in itself makes it interesting from a science standpoint. And I'd be surprised if other cancers didn't start popping up elsewhere given a more normal timeframe - unless somehow this the BRAF driven creation of cancer is unique to squamous cells (which seems unlikely to me). So this would seem to be a treatment that will always be a treatment of last resort (e.g. not prophylactic after resection of nodes).