Replies to post #102684 on Biotech Values

[iwfal]

ligand-driven cancers

Ok, I'll bite - what is a "ligand driven cancer" and how is it different than a "mutation driven cancer" - since to my knowledge all cancers are ultimately mutation driven?

THE DRUG, IMO, is JUNK, in ligand-driven cancers (as seen in two recent Phase 2 trials - colon cancer and ovarian cancer).

Are you saying that for colon and ovarian cancer the mutation is elsewhere (in non-hedgehog pathways) and only indirectly (how?) effects the hedgehog pathways? Or are you saying something different?