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iwfal

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iwfal

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Re: BTH post# 102684

Friday, 08/27/2010 6:36:13 AM

Friday, August 27, 2010 6:36:13 AM

Post# of 252588

ligand-driven cancers



Ok, I'll bite - what is a "ligand driven cancer" and how is it different than a "mutation driven cancer" - since to my knowledge all cancers are ultimately mutation driven?


THE DRUG, IMO, is JUNK, in ligand-driven cancers (as seen in two recent Phase 2 trials - colon cancer and ovarian cancer).



Are you saying that for colon and ovarian cancer the mutation is elsewhere (in non-hedgehog pathways) and only indirectly (how?) effects the hedgehog pathways? Or are you saying something different?
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