Replies to post #100667 on Biotech Values

[poorgradstudent]

>I think you and dewophile are using the word systemic differently than I am. Yes, leg compression has some beneficial effect all over the body. But would leg compression be considered a valid means of preventing a clot in, say, the coronary arteries following a stent procedure? <

People suffering from MI achieve better myocardial salvage at 24 hours when they're getting a repeat inflation-deflation cycle (200 mm Hg) from a cuff around their *arm* during transport to the hospital (Lancet article from 2010).

This doesn't mean that the procedure is directly resolving a clot in your coronary artery and that you should take a pass on PCI or anticoagulants. However, the fact that the compression is occurring around the left arm yet is having an impact on rescuing myocardium supports the notion that the benefit is achieved through a systemic mechanism.

[dewophile]

I think you and dewophile are using the word systemic differently than I am. Yes, leg compression has some beneficial effect all over the body. But would leg compression be considered a valid means of preventing a clot in, say, the coronary arteries following a stent procedure?

my recollection is that the primary MOA of leg compression is NOT mechanical but rather due to release of some endogenous anticoagulants - so i do mean a systemic effect in the true sense. i'm sorry i have no references or can't be more specific. regardless from an investing standpoing i think it is moot - i was raising it for purely academic reasons. i don't see mechanical compression displacing lovenox at all in the foreseeable future