Replies to post #201603 on Xechem International Inc. (fka XKEM)

[Eli's Gone]

People with the sickle cell trait have one copy of the sickle cell gene. Two copies of the sickle cell gene yield the full sickle cell disease.


Pathologic processes that cause hypoxia, acidosis, dehydration, hyperosmolality, hypothermia, or elevated erythrocyte 2,3-DPG can transform silent sickle cell trait into a syndrome resembling sickle cell disease with vaso-occlusion due to rigid erythrocytes

Let me use my kindergarden crayon...

I speak of two distinct groups:

A. those with SC Trait
B. those with SC Disease

I will refer to those in Group A as carriers...IMVHO the carriers are indeed highly predisposed to the following:

A summary of the risks associated with sickle cell trait is as follows.

1. Splenic infarction at high altitude, with exercise, or with hypoxemia
2. Isothenuria with loss of maximal renal concentrating ability
3. Hematuria secondary to renal papillary necrosis
4. Fatal exertional heat illness with exercise
5. Sudden idiopathic death with exercise
6. Glaucoma or recurrent hyphema following a first episode of hyphema
7. Bacteruria in women
8. Bacteruria or pyelonephritis associated with pregnancy
9. Renal medullary carcinoma in young people (ages 11 to 39 years)
10. Early onset of end stage renal disease from autosomal dominant polycystic kidney dise