Did you notice that the short interest in ACHN increased over ten-fold in the two week period 12/15/09 to 12/31/09?
There are still only about 4% of shares short as of 12/31/09 according to Yahoo. That's not much at all. But, I guess you're implying that the spike is possible evidence that someone knew of, and acted upon, the forthcoming offering. I don't normally pay much attention to short interest ratios or spikes in them, but perhaps that's something to consider in the future.
It's to be expected when you get giant volume days inside the parameter of "average daily volume". The days to cover is still within 1-3 and that is based on average daily volume too. If the average daily volume falls to a more reasonable 200K per day the 795K shorts will take longer to cover without a pop.
I own no ACHN but I think they are waiting for the gap to close, and it should, soon.